The Raptors won 131-127 in overtime.
DeRozan’s 52 points were also a new personal best, surpassing the 45-point game he had earlier this season against the Philadelphia 76ers.
DeRozan made 17 of 29 field goal attempts and shot 13-for-13 at the free throw line. His five 3-pointers were one shy of his career high. He scored the first nine points of the game and had 21 in the first quarter, the most by a Raptors player in a quarter this season.
DeRozan added 8 assists, 5 rebounds, 1 steal and 1 block.
The Associated Press contributed to this report.